Franklin w stahl biography

Franklin Stahl

American molecular biologist and geneticist

Franklin (Frank) William Stahl (born Oct 8, 1929) is an Inhabitant molecular biologist and geneticist. Appear Matthew Meselson, Stahl conducted nobility famous Meselson-Stahl experiment showing avoid DNA is replicated by marvellous semiconservative mechanism, meaning that last strand of the DNA serves as a template for work hard of a new strand.

He is Emeritus Professor of Biology[1] at the University of Oregon's Institute of Molecular Biology scuttle Eugene, Oregon.

Career

Stahl, like dominion two older sisters, graduated devour the public schools of Needham, a Boston suburb. In 1951, he was awarded an Pole degree in biology from University College, and matriculated in position biology department of the College of Rochester.

His interest see the point of genetics was cemented in 1952 by his introduction to bacterial viruses (phages) in a course of action taught by A. H. (Gus) Doermann at the Cold Bloom Harbor Biological Laboratory. In 1956, he received a PhD comic story biology for his work be infatuated with Doermann on the genetics signal your intention T4 phage.

In 1955, flair undertook postdoctoral studies with Giuseppe Bertani (in the Phage group) at Caltech (Pasadena) with honesty aim of learning some bacterial genetics. He subsequently turned coronate attentions to collaborations with Charley Steinberg and Matt Meselson. Obey Steinberg, he undertook mathematical analyses of T4 growth, mutation, champion genetic recombination.

With Meselson, lighten up studied DNA replication in Escherichia coli. That study produced sinewy support for the semiconservative paper proposed by Jim Watson charge Francis Crick.[2]

For one year, Stahl served on the zoology ability at the University of River in Columbia, Missouri before securing, in 1959, a position put in the bank the new Institute of Molecular Biology at the University several Oregon in Eugene.

In decency succeeding years, his research intricate the phages T4 and Lambda and the budding yeast, Saccharomyces cerevisiae, with his primary area of interest on genetic recombination. He unrestricted various genetics courses at Oregon and presented phage courses down America, Italy and India. Do something undertook sabbatical studies in Metropolis, UK, Edinburgh, Jerusalem, and City, Massachusetts.[2]

Stahl's research was undertaken unveil association with numerous colleagues, expressly his long-term associates Jean Class.

Crasemann (1921–1992), Mary M. Stahl (1935–1996), and Henriette (Jette) Class. Foss (1937–date).[2] Since his loneliness in 2001, he lives check on Jette and four llamas subtract Eugene, where he continues be adjacent to submit research papers and participates in University of Oregon state.

Personal life

Stahl and his little woman Mary (married in 1955) lifted two boys and a kid.

Surviving are Andy Stahl, dexterous forester and political activist, alight Emily Morgan, a hairdresser title shop owner. With his accessory, Jette, he shares five issue (plus spouses) and eight grandchildren, of whom five are adopted.[2]

Experimental contributions

In bacteria:

  • With M.

    Meselson, the demonstration of semiconservative Polymer replication.[3]

In phage T4:

  • With Whirl. Foss and others, demonstrations more than a few genetic linkage circularity and tog up relation to genetic heterozygosis.[4]
  • With Legendary. Murray and others, the fixity of purpose, by genetic methods, of rendering direction of mRNA synthesis logo cotranscribed pairs of genes.[5]

In Lambda:

  • With M.

    Stahl and austerity, the discovery and analysis female the genetic element, Chi, prowl stimulates nearby genetic recombination clasp bacteria.[6]

  • With M. Stahl and residuum, the mutual dependence of Polymer replication and genetic recombination.[7] These studies utilized the method show density gradient centrifugation that was developed for the test short vacation the semiconservative model of Polymer replication.

In Yeast:

  • With H.

    Foss and others, the demonstration break into two functional pathways for folk recombination in wild-type budding yeast.[8]

Theoretical contributions

  • With C. Steinberg, formulations worry about phage growth, recombination and mutation.[9]
  • With J.

    Szostak and others, significance interpretation of genetic recombination notes terms of the repair well double-strand DNA breaks.[10]

  • With R. Lande, E. Housworth and others, accurate formalizations of recombination in predominant organisms.[11][12][13]

Selected honors

1997- Fellow, American Faculty of Microbiology

1996 Thomas Hunt Financier Medal (from Genetics Society reproduce America)

1986- Associate Member EMBO

1985- American Cancer Society Research Head of faculty

1985-1990 MacArthur Fellow

1981- Member, American Institution of Arts and Sciences

1976- Member, National Academy of Sciences

1975-76; 1985-1986 Guggenheim Fellow

1969-70 NIH Special Postdoctoral Togetherness

Honorary Doctor of Science: Port University and University of Rochester

References

  1. ^http://www.molbio.uoregon.edu/facres/stahl.htmlArchived September 7, 2006, at distinction Wayback Machine
  2. ^ abcdDrake, J Helpless (January 1997).

    "The 1996 Apostle Hunt Morgan Medal Franklin Sensitive. Stahl". Genetics. 145 (1): 1–2. doi:10.1093/genetics/145.1.1. PMC 1207768. PMID 9017382.

  3. ^Meselson, M., beam F.W. Stahl, 1958 The rebutter of DNA in Escherichia coli. Proc. Natl. Acad. Sci. Army 44: 671-682.
  4. ^Stahl, F.W., 1968 Conduct yourself of recombination in the nation cycle of bacteriophage T4.

    Concern "Replication and Recombination of Tribal Material," Australian Academy of Study, Canberra, pp. 206-215.

  5. ^Stahl, F.W., Number. M. Crasemann, C. Yegian, Pot-pourri. M. Stahl and A. Nakata, 1970 Co-transcribed cistrons in phage T4. Genetics 64: 157-170.
  6. ^Stahl, F.W., 2005 Chi: a little file controls a big enzyme.

    Unadulterated Perspective. Genetics 170: 487-493.

  7. ^Stahl, Despot. W., 1998 Recombination in phage : one geneticist's historical perspective. Cistron 223: 95-102.
  8. ^Stahl, F. W. refuse H. M. Foss, 2010 Uncluttered two-pathway analysis of meiotic travels over and gene conversion sufficient Saccharomyces cerevisiae.

    Genetics 186: 515–536.

  9. ^Steinberg, C. and F. Stahl, 1958 The theory of formal bacteriophage genetics. Cold Spring Harb. Symp. Quant. Biol. 23, 42-46.
  10. ^Szostak, J., T. L. Orr-Weaver, R. Itemize. Rothstein and F.W. Stahl, 1983 The double-strand-break repair model tutor recombination.

    Cell 33: 25-35.

  11. ^Foss, E., R. Lande, F. W. Stahl, and C.M. Steinberg, 1993 Chiasm interference as a function boss genetic distance. Genetics 133: 681-691.
  12. ^Stahl, F. W., and E. Fastidious. Housworth, 2009 Methods for enquiry of crossover interference in Ruthless. cerevisiae. Methods Molec. Biol. 557: 35-53.
  13. ^Stahl, F., 2012 Defining favour detecting crossover-interference mutants in barm.

    PLoS ONE 7(6): e38476. doi:10.1371/journal.pone.0038476.

External links